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      霍亂毒素B亞單位,CTB

      簡要描述:Cholera toxin (CTB,霍亂毒素B亞基)belongs to the AB5 –subunit family oftoxins.The native hexameric protein has a molecular mass of ~85 kDa and contains two subunits. It consists of a single A subunit (~27.2

      • 產品型號:abs80001
      • 廠商性質:生產廠家
      • 更新時間:2023-06-15
      • 訪  問  量:2969

      詳細介紹

      品牌absinCAS131096-89-4
      純度≥95%分子量11kd
      貨號abs80001規格1mg
      供貨周期現貨主要用途Cholera toxin and its purified A subunit
      應用領域生物產業


      產品描述
      描述

      Cholera toxin (CTB,霍亂毒素B亞基)belongs to the AB5 –subunit family oftoxins.The native hexameric protein has a molecular mass of ~85 kDa and contains two subunits. It consists of a single A subunit (~27.2 kDa), responsible for the ADP-ribosylation activity, and five B subunits(~11.6 kDa each), which are arranged as a pentameric ring with an apparent 5-fold symmetry and are associated with the cell surface receptor binding and subsequent internalization (transmembrane transport)of the enzymatic component.

      來源
      E.coli
      純度
      ≥95%
      儲存/保存方法
      2–8 °C, The product, as supplied, is stable 2 years when stored properly. Solutions are stable for at least 3 months when stored at 2–8 °C. DO NOT FREEZE.
      技術指標

      Format:Recombinant
      Sodium azide:Not add.

      產品用途
      Cholera toxin and its purified A subunit are frequently used for the study of signal transduction mechanisms.In addition,cholera toxin acts as an adjuvant through the stimulation of B lymphocytes. The cholera toxin B subunit alone is used for track tracing in neurological research, taking advantage of GM1 ganglioside binding and retrograde transport.Tissue culture cells treated with cholera toxin are not killed and tissues of animals do not become necrotic.
      注意事項
      The B subunit is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. The cholera toxin B subunit (CTB) attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. The B subunit has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Recently it has been widely used as a marker of membrane lipid rafts, which are membrane microdomains enriched with cholestrol and sphingolipids. These lipid rafts have an important role in cell signaling and protein trafficking.
      基本信息
      別名
      霍亂毒素B亞基、CHOLERA TOXIN B SUBUNIT、CTB、 Cholera Toxin B subunit、CTxB、Choleragenoid
      外觀
      powder
      可溶性/溶解性
      H2O: soluble 1mg/mL
      參考文獻
      參考文獻
      1. Nedelkoska, L., and Benjamins, J.A., Binding of cholera toxin B subunit: a surface marker for murine microglia but not oligodendrocytes or astrocytes. J. Neurosci. Res., 53, 605-612 (1998).
      2. Janes, P.W., et al., Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol., 147, 447-461 (1999).


       

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